On May 26, 2017 the World Health Assembly (WHA), the WHO’s decision-making body, adopted a resolution on improving the prevention, diagnosis, and management of sepsis. The first action urged by the resolution was for member states to develop national policy and processes to improve the prevention, diagnosis, and treatment of sepsis; this is best articulated as a national Action plan for sepsis. In this Plenary session, world experts will address some exciting progress and remaining challenges in high, middle and low-income countries and how realistic and achievable actions can save literally millions of lives.